Bioreversible Protection of Nucleoside Diphosphates

Henning Jacob Jessen, Tilmann Schulz, Jan Balzarini, Chris Meier
Published Online: Oct 2 2008 9:17AM
DOI: 10.1002/anie.200803100

	Going incognito: A new prodrug approach has been developed to facilitate the diffusion of highly polar polyphosphorylated nucleosides across cell membranes (see scheme). Inside the cell, the masking groups on the nucleoside diphosphate should be cleaved rapidly by enzymes to release the antiviral active cargo.