Chemical Approaches to DNA Nanotechnology

http://www3.interscience.wiley.com/cgi-bin/fulltext/122579503/PDFSTART

CELL-SELEX: Novel Perspectives of Aptamer-Based Therapeutics

Int J Mol Sci. 2008, 9, 668

Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.