I thought Basri would appriciate these since he gave a good lit talk on the SILAC technique a while back. These two papers (this link is to the 2 page commentary also in Nature) raise many questions about how miRNA downregulate protein expression while only minamally affecting mRNA levels. Very biology, proteomics, bioinformatics if you are interested…
D. Baek, J. Villen, C. Shin, F. D. Camargo, S. P. Gygi, and D. P. Bartel. The impact of microRNAs on protein output. Nature, 2008.
M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky. Widespread changes in protein synthesis induced by microRNAs. Nature, 2008.
